Biodistribution of therapeutic extracellular vesicles

The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past two decades, from being regarded as cellular waste bags to considered essential mediators intercellular communication. Their unique ability transfer macromolecules across cells and biological barriers made them rising star drug delivery. Mounting evidence suggests that EVs can be explored efficient delivery vehicles for range therapeutic macromolecules. In contrast many synthetic systems, these appear exceptionally well tolerated vivo. This development application been through technological advancement labelling understanding vivo biodistribution EVs. Here this review, we have summarised recent findings EV pharmacokinetics discussed various need surpassed achieve tissue-specific